First circumnavigation of the globe by a ship of Ferdinand Magellan's expedition. Only one ship survived the journey, under the command of the Basque captain Sebastian Elkano (1522).
Copernicus publishes his theory that the Earth and the other planets revolve around the Sun (1543)
The Council of Trent (1545 - 1563), one of the ecumenical councils of the Catholic Church, defined a large number of new dogmas in response to the Protestant Reformation.
In the Dutch revolt of 1568-1648, a small nation gained independence from the superpower of the day (Spain).