Hughes the recluse
As time passed, Hughes descended into a reclusive, drug-addled life locked in darkened rooms and terrified of germs. He moved from hotel to hotel, from the Beverly Hills Hotel to Boston to Las Vegas, where he bought the Desert Inn (because they threatened to evict him) and several other hotel/casinos (Castaways, New Frontier, Landmark, Sands and Silver Slipper) - he was known for modernizing Las Vegas by buying it from the Mafia. He bought television stations such as KLAS-TV in Las Vegas so that there would be something to watch when he was up all night with insomnia. He became addicted to codeine and other painkillers, was extremely frail, wore Kleenex boxes as shoes, and stored his urine in jars. As he deteriorated, he ended up moving to the Bahamas, Vancouver, London, and several other places, always in the top floor penthouse with the windows blacked out - and every time he moved out the hotel seemed to need to remodel to clean up after him. Hughes died on an airplane enroute from his penthouse in Mexico to the Methodist Hospital in Houston.
Hughes as fictional inspiration
The following fictional characters appear to have been, in part, patterned after Hughes: