Lack of an absolute reference frame
Special Relativity rejects the idea of any absolute ('unique' or 'special') frame of reference; rather physics must look the same to all observers travelling at a constant velocity (inertial frame). This 'principle of relativity' dates back to Galileo, and is incorporated into Newtonian Physics. In the late 19th Century, some physicists suggested that the universe was filled with a substance known as "aether" which transmited Electromagnetic waves. Aether constituted an absolute reference frame against which speeds could be measured. Aether had some wonderful properties: it was sufficiently elastic that it could support electromagnetc waves, those waves could interact with matter, yet it offered no resistance to bodies passing through it.
The results of various experiments, culminating in the famous Michelson-Morley experiment, suggested that either the Earth was always 'stationary', or the notion of an absolute frame of reference was mistaken and must be discarded.
Equivalence of mass and energy
As the velocity of an object increases, so does it mass, and the increase in mass is equal to 1/c2 times the increase in energy. I.e.
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where m = γ m0, , E is the energy of the object, m0 is the rest mass, c is the speed of light, v is the velocity of the object. The term γ occurs frequently in relativity, and comes from the Lorentz transformation equations.
The equivalence of mass and energy turns out to be fundamental. The destruction of mass in nuclear reactions releases vast amounts of energy.
It is worth noting that if v is much less than c then
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which is the rest energy, m0c2, plus the Newtonian